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Is C-Reactive Protein an Inflammation Opsonin That Signals Colon Cancer Risk?
Boris Pasche, MD, PhD;
Charles N. Serhan, PhD
JAMA. 2004;291:623-624.
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Colorectal cancer is a leading cause of cancer-related morbidity and mortality in the Western world. A personal history of inflammatory bowel disease (IBD) is a well-established risk factor for colorectal cancer. Recent data suggest that the risk of colorectal cancer for individuals with IBD increases by 0.5% to 1.0% yearly, 8 to 10 years after diagnosis.1 The magnitude of colorectal cancer risk increases with early age at IBD diagnosis, longer duration of symptoms, and extent of the disease.1 In addition, a wealth of experimental, epidemiological, and randomized trial evidence suggests that long-term use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the risk of colorectal adenoma and cancer.2-4 In both instances, the duration of either the inflammatory process or the use of anti-inflammatory agents is emerging as a key predictor of increased and decreased colorectal cancer risk, respectively.
In this . . . [Full Text of this Article] What Would Lead to Elevated CRP Level in Colon Cancer?
Author Affiliations: Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Ill (Dr Pasche). Dr Pasche is a Contributing Editor, JAMA. Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (Dr Serhan).
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