This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Revascularization  • Thrombolysis  • Cardiovascular System  • Surgery  • Surgical Interventions  • Cardiovascular/ Cardiothoracic Surgery  • Cardiovascular Intervention  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: In response to Dr Goodman, we convened an independent blinded end point committee to ensure unbiased assessment of events, as we stated in our article. Goodman is concerned about the differentiation between index infarctions that justified inclusion in the study and infarctions that subsequently occur as a complication. Indeed, this a problem in any study that includes patients with non–ST-elevation myocardial infarction and that concerns infarctions occurring within the first 8 hours after study entry. In our study, myocardial infarction within 8 hours from randomization occurred in 5 patients in the early intervention group and 6 patients in the prolonged pretreatment group. If anything, these infarctions may have blunted the principal finding of our study. If we exclude them from the analysis, the disadvantage of the prolonged pretreatment becomes even more pronounced (relative risk, 2.5 [95% confidence interval, 1.1-6.0]).

Goodman observes that the cumulative incidences for our primary . . . [Full Text of this Article]

Franz-Josef Neumann, MD
Herz-Zentrum Bad Krozingen
Krozingen, Germany

Adnan Kastrati, MD; Albert Schömig, MD
Deutsches Herzzentrum München
Klinik an der Technischen Universität München
Munich, Germany

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

"Cooling-Off" vs Immediate Revascularization for Patients With Acute Coronary Syndromes
Shaun Goodman
JAMA. 2004;291(6):691.
EXTRACT | FULL TEXT  

Evaluation of Prolonged Antithrombotic Pretreatment ("Cooling-Off" Strategy) Before Intervention in Patients With Unstable Coronary Syndromes: A Randomized Controlled Trial
Franz-Josef Neumann, Adnan Kastrati, Gisela Pogatsa-Murray, Julinda Mehilli, Hildegard Bollwein, Hans-Peter Bestehorn, Claus Schmitt, Melchior Seyfarth, Josef Dirschinger, and Albert Schömig
JAMA. 2003;290(12):1593-1599.
ABSTRACT | FULL TEXT