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Regulation of Synovial Adipocytokines—Reply
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In Reply: Dr Stefan and colleagues suggest that corticosteroids might influence the levels of adipocytokines. Although this is a possibility, none of our patients with OA were receiving corticosteroids or other immunosuppressive therapy. Furthermore, in the subgroup of patients with RA, partial correlation analysis did not show any correlation between adipocytokines and concomitant medication. In addition, none of the patients with RA were receiving TNF- inhibitors.
We disagree with the suggestion of Stefan et al that our study found a nonnegative association between BMI and either adiponectin or resistin. As expected, patients with OA had significantly higher BMI than patients with RA. However, as mentioned in our article, partial correlation analysis revealed nonsignificant correlations between BMI and concentrations of adiponectin (r = 0.246, P = .08) and resistin (r = 0.245, P = .07).
We also doubt their speculation that serum levels reflect synovial fluid levels of inflammatory . . . [Full Text of this Article]
Andreas Schäffler, MD;
Ulf Müller-Ladner, MD
Department of Internal Medicine I
University of Regensburg
Regensburg, Germany
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Adipocytokines in Synovial Fluid
Andreas Schäffler, Angela Ehling, Elena Neumann, Hans Herfarth, Ingo Tarner, Jürgen Schölmerich, Ulf Müller-Ladner, and Steffen Gay
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RELATED ARTICLE
Regulation of Synovial Adipocytokines
Norbert Stefan, Hans-Ulrich Häring, and Michael Stumvoll
JAMA. 2004;291(6):694-695.
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