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To the Editor: Dr Rosenheck and colleagues¹ reported improvement of approximately 15 points in symptom scores in the group treated with olanzapine vs an approximately 10-point difference in those treated with haloperidol. The authors did not perform statistical comparisons within each group, however; thus, it is difficult to know if these differences are statistically significant or clinically meaningful.

A lack of within-group improvement would suggest that the study sample was composed of treatment-resistant patients, which may then explain the lack of between-group difference.

Michal Kunz, MD
michal.kunz@med.va.gov
Huntington Veterans Affairs Medical Center
Huntington, WV

1. Rosenheck R, Perlick D, Bingham S, et al. Effectiveness and cost of olanzapine and haloperidol in the treatment of schizophrenia: a randomized controlled trial. JAMA. 2003;290:2693-2702. FREE FULL TEXT

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291:1065.

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