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Inflammation and Age-Related Macular Degeneration—Reply
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In Reply: We reported the first association between high-sensitivity C-reactive protein levels and age-related macular degeneration. As we stated, the role of inflammation is biologically plausible based on previous research, including the association of neovascularization with inflammatory eye diseases. We also noted that there is an evolving hypothesis that inflammation is associated with the pathogenesis of AMD, and that our clinical results lend support to that potential mechanism. Furthermore, we recognized that additional epidemiologic as well as basic research is needed to sort out whether the association with inflammation is primary (ie, causal or predictive) or secondary (ie, a reaction to other stimuli).
We appreciate Dr Penfold providing his and other additional references and acknowledge their relevance to this growing body of literature. We look forward to additional advances from basic and clinical researchers on this important topic.
See original article for author affiliations (JAMA. 2004;291:704-710).—ED.
Johanna M. Seddon, MD, ScM
johanna_seddon@meei.harvard.edu
Gary Gensler, MS;
Roy C. Milton, PhD;
Michael L. Klein, MD;
Nader Rifai, PhD
Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.
JAMA. 2004;292:43.
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Association Between C-Reactive Protein and Age-Related Macular Degeneration
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