 |
|
Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
To the Editor: Dr Fox and colleagues1 report the results of an analysis performed within the Framingham Heart Study, showing that parental atrial fibrillation (AF) increases the future risk for AF in offspring. However, the reasons for the genetic susceptibility to developing AF remained unexplained. One factor the authors did not investigate was the extent to which the genetic risk of AF varied according to left atrial size in parents and offspring. We have previously reported an echocardiographic study on 251 healthy young individuals and their parents in which we found that parental and offspring atrial dimensions were significantly correlated with one another.2 The proportion of variance in the offspring left atrial dimension explained by parental atrial dimension was 3.6%, increasing to 6.3% when left ventricular mass and left ventricular diastolic function were accounted for. Left atrial enlargement is an important predictor of AF,3 and spontaneous conversion to sinus rhythm . . . [Full Text of this Article]
Paolo Palatini, MD
palatini@unipd.it
Department of Clinical and Experimental Medicine
University of Padova
Padova, Italy
RELATED ARTICLES
Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring—Reply
Caroline S. Fox, Ramachandran S. Vasan, and Emelia J. Benjamin
JAMA. 2004;292(10):1175.
EXTRACT
| FULL TEXT
Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring
Caroline S. Fox, Helen Parise, Ralph B. D'Agostino, Sr, Donald M. Lloyd-Jones, Ramachandran S. Vasan, Thomas J. Wang, Daniel Levy, Philip A. Wolf, and Emelia J. Benjamin
JAMA. 2004;291(23):2851-2855.
ABSTRACT
| FULL TEXT
|
