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A Great Idea Switches From Ignored to Irresistible

Drummond Rennie, MD

JAMA. 2004;292:1359-1362.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In a recent article in JAMA on the registration of clinical trials,¹ Dickersin and I pointed out that, 30 years after the idea of registering trials had been proposed, 18 years after registration of trials at inception had been shown to eliminate publication bias, and despite the presence of numerous trial registers large and small, Manheimer and Anderson² were correct in stating that "No comprehensive system for tracking, organizing, and disseminating information about ongoing clinical trials currently exists." We described a profound confusion about even the most basic data from, or existence of, clinical trials. Only half of the million or so trials conducted over the past 56 years are likely to have been reported,¹ and of those reported, a substantial proportion did not appear in MEDLINE.

One consequence of this lack of reporting is a persistent bias in favor of positive results and therefore in favor . . . [Full Text of this Article]

RECENT DEVELOPMENTS

AMA Initiative

Pharmaceutical Industry Response

Can Manufacturers Produce a Worthwhile Register?

Political Response

What Trials Should Be Registered and When?

The International Committee of Medical Journal Editors Initiative

Addendum

Author Affiliation: Dr Rennie is Deputy Editor, JAMA.

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