This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Cardiovascular System  • Women's Health  • Women's Health, Other  • Cardiovascular Disease/ Myocardial Infarction  • Alert me on articles by topic  Social Bookmarking   What's this?

Estrogen Receptor Polymorphisms and the Risk of Myocardial Infarction—Reply

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: Although we do not have information about oral health for the participants in the Rotterdam Study, we do have extensive information on osteoporosis and bone mineral density. The association reported by Dr Taguchi and colleagues between ESR1 polymorphisms and postmenopausal tooth loss in postmenopausal women is in line with an association we found in men and women between these polymorphisms and osteoporosis.¹ The same haplotype found to be associated with risk of MI in postmenopausal women² was also associated with lumbar spine bone mineral density (BMD) and vertebral fracture risk in these same women. Taguchi suggests that the association we found between ESR1 polymorphisms and ischemic heart disease may not be a causal relationship but rather an indirect result of the associations between ESR1 polymorphisms and tooth loss, and between tooth loss and risk of MI.

Since it has been suggested that BMD and periodontal disease are . . . [Full Text of this Article]

Stephanie C. E. Schuit, MD; André G. Uitterlinden, PhD; Huibert A. P. Pols, MD, PhD
h.pols@erasmusmc.nl
Department of Internal Medicine
Erasmus Medical Center
Rotterdam, the Netherlands

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Estrogen Receptor Polymorphisms and the Risk of Myocardial Infarction
Akira Taguchi
JAMA. 2004;292(14):1683.
EXTRACT | FULL TEXT  

Estrogen Receptor Gene Polymorphisms and Risk of Myocardial Infarction
Stephanie C. E. Schuit, Hok-Hay S. Oei, Jacqueline C. M. Witteman, Corine H. Geurts van Kessel, Joyce B. J. van Meurs, Rogier L. Nijhuis, Johannes P. T. M. van Leeuwen, Frank H. de Jong, M. Carola Zillikens, Albert Hofman, Huibert A. P. Pols, and André G. Uitterlinden
JAMA. 2004;291(24):2969-2977.
ABSTRACT | FULL TEXT