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To the Editor: There is evidence that older male carriers of premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene are at high risk of developing the fragile X–associated tremor/ataxia syndrome¹ and spinocerebellar ataxia.² Since the phenotypes associated with these disorders overlap with those of Parkinson disease (PD) and essential tremor, we sought to determine the prevalence of FMR1 premutation alleles in men with these movement disorders.

Methods

From our DNA bank we conducted FMR1 premutation analysis in 216 men with idiopathic PD excluding atypical cases (mean age at symptom onset, 56.3 [SD, 12.2] years) and in 196 male patients with typical essential tremor (mean age at symptom onset, 53.7 [SD, 14.3] years). Genomic DNA was isolated from peripheral blood and amplification of DNA was carried out using the GC-RICH polymerase chain reaction System (Roche Diagnostics, Indianapolis, Ind). The CGG repeats were detected on . . . [Full Text of this Article]

Hao Deng, PhD; Weidong Le, MD, PhD; Joseph Jankovic, MD
josephj@bcm.tmc.edu
Parkinson Disease Center and Movement Disorders Clinic
Department of Neurology
Baylor College of Medicine
Houston, Tex

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