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Optimizing the Response to a Common Threat

James F. Toole, MD; David C. Sane, MD; Kerstin Bettermann, MD, PhD

JAMA. 2004;292:1885-1887.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of JAMA, the articles by Tran and Anand¹ and Spagnoli and colleagues² contribute useful information about prevention of ischemic stroke. Tran and Anand rightly consider that atherosclerosis is a patchy disease for which platelet anti-aggregants, in addition to reduction of modifiable risk factors, are recommended and have chosen transient ischemic attack (TIA) and cerebral infarction as the indices for the successful intervention. The authors consider aspirin alone and in combination with clopidogrel, ticlopidine, and dipyridamole and conclude that clopidogrel alone or with aspirin is the most efficacious method for primary and secondary prevention of TIA and recurrent ischemic stroke. However, they concentrate only on antiplatelet therapy and do not specifically address the important effects of diet, lipids, exercise, smoking, and other modifiable risk factors.

As reviewed by Tran and Anand, aspirin and clopidogrel (or combined . . . [Full Text of this Article]

Author Affiliations: Departments of Neurology (Drs Toole and Bettermann) and Cardiology (Dr Sane), Wake Forest University School of Medicine, Winston-Salem, NC.

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