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Catherine D. DeAngelis, MD, MPH; Annette Flanagin, RN, MA

JAMA. 2004;292:1889.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Tuberculosis (TB) has been infecting and killing humans for more than 3000 years.¹ Despite the many advances of modern medicine, TB remains one of the world’s leading infectious causes of death. Currently one third of the world’s population is infected with the TB bacillus and approximately 2 million individuals die each year of TB,² with more than 90% of infections and deaths occurring in low- and middle-income countries.³ In 2000, an estimated 8.7 million new cases of TB were reported, and approximately 2% to 3% were multidrug-resistant.⁴ In addition, TB is the leading cause of morbidity and mortality among individuals infected with the human immunodeficiency virus (HIV),² who have a greater risk of developing the disease.⁵

While 23 countries account for 80% of all new TB cases, more than half are concentrated in 5 countries (Bangladesh, China, India, Indonesia, and Nigeria).⁶ . . . [Full Text of this Article]

Author Affiliations: Dr DeAngelis is Editor-in-Chief and Ms Flanagin is Managing Senior Editor, JAMA.

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