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History of Emerging Vascular Disease Risk Factors
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To the Editor: The review of emerging risk factors for atherosclerotic vascular disease by Drs Hackam and Anand,1 while describing recent evidence quite well, illustrates one of the pitfalls of limiting literature searches to relatively recent years. Had they expanded their search to earlier years, they might have noted articles describing the discovery of and providing insight into biochemical mechanisms of processes they reviewed.
Five decades ago we reported the discovery of the role played by the amino acid methionine in the transmethylation of 1-carbon methyl groups in experimental atherogenesis.2 The scientific literature on amino acid metabolism at that time indicated that limited biosynthesis of methionine occurred in mammals by homocysteine serving as a receptor for 1-carbon methyl groups. We therefore hypothesized that a deficiency in the biosynthesis of the 1-carbon methyl group could generate not only an increase in homocysteine, but also a deficiency in methionine as a methyl . . . [Full Text of this Article]
Laurence Pilgeram, PhD
arnold@lifesci.ucsb.edu
University of California, Santa Barbara
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