 |
|
Role of Toll-like Receptor 4 in Acute Myocardial Infarction and Longevity
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
To the Editor: A major trait characterizing centenarians is a relatively low frequency of cardiovascular disease (CVD). Since a proinflammatory genotype appears to contribute to the risk of ischemic heart disease, the prevalence of proinflammatory alleles would also be expected to be relatively low in people experiencing longevity.1 Toll-like receptor 4 (TLR4), the activity of which may be modulated by genetic polymorphisms, is a signaling receptor in innate immune defense. It is activated by lipopolysaccharide from gram-negative bacteria and endogenous ligands, including those produced in response to tissue injury. TLR4 is expressed on virtually all cells. However, in atherosclerotic tissue its expression is markedly up-regulated, and the inflammatory mediators produced by its activation exert various atherogenic effects.2-3 In this study, we evaluated whether prevalence of the TLR4 genotype may have an association with acute myocardial infarction (AMI) and with longevity.
Methods. We studied 105 young Sicilian men (mean . . . [Full Text of this Article]
Carmela Rita Balistreri, SciD;
Giuseppina Candore, PhD;
Giuseppina Colonna-Romano, SciD;
Domenico Lio, MD
Immunosenescence Unit
Department of Pathobiology and Biomedical Methodologies
University of Palermo
Palermo, Italy
Marco Caruso, MD;
Enrico Hoffmann, MD
Department of Internal Medicine
Cardiovascular and Nephro-Urological Diseases
University of Palermo
Claudio Franceschi, MD
Italian National Research Center on Aging
Ancona, Italy
Department of Experimental Pathology and Interdepartmental Center "L. Galvani"
University of Bologna
Bologna, Italy
Calogero Caruso, MD
marcoc@unipa.it
Immunosenescence Unit
Department of Pathobiology and Biomedical Methodologies
University of Palermo
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A Genetic-Demographic Approach Reveals Male-Specific Association Between Survival and Tumor Necrosis Factor (A/G)-308 Polymorphism
Cardelli et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2008;63:454-460.
ABSTRACT
| FULL TEXT
Review: Variability of host pathogen interaction
Hermann
Innate Immunity 2007;13:199-218.
ABSTRACT
Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage
Hirschfeld et al.
Hum Reprod 2007;22:440-443.
ABSTRACT
| FULL TEXT
Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population
Koch et al.
Eur Heart J 2006;27:2524-2529.
ABSTRACT
| FULL TEXT
Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population
Grimaldi et al.
J. Leukoc. Biol. 2006;79:611-615.
ABSTRACT
| FULL TEXT
|
