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To the Editor: In considering the results of the study by Dr Esposito and colleagues¹ on the effect of weight reduction on erectile dysfunction in obese men, it is interesting to look at some of the older literature that addressed thiazide-induced erectile dysfunction and found improvement with weight loss among individuals who were obese.^2-3 That finding becomes better explained given the improvement in endothelial function with weight loss found in the present study.

Michael Bursztyn, MD
bursz@cc.huji.ac.il
Hadassah University Hospital, Mount-Scopus
Jerusalem, Israel

1. Esposito K, Giugliano F, Di Palo C, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA. 2004;291:2978-2984. FREE FULL TEXT 2. Wassertheil-Smoller S, Blaufox MD, Oberman A, et al. Effect of antihypertensives on sexual function and quality of life: the TAIM Study. Ann Intern Med. 1991;114:613-620. FREE FULL TEXT 3. Langford HG, Rockhold RW, Wassertheil-Smoller S, et al. Effect of weight loss on thiazide produced erectile problems in men. Trans Am Clin Climatol Assoc. 1989;101:190-194. PUBMED

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292:2466.

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