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Obesity and Atrial Fibrillation
Is One Epidemic Feeding the Other?
James Coromilas, MD
JAMA. 2004;292:2519-2520.
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Obesity has reached epidemic proportions in the United States; nearly 65% of the population is overweight and nearly 31% is obese.1 Similarly, atrial fibrillation (AF) is reaching epidemic proportions,2 with nearly 2.5 million Americans currently affected. As the population ages, it is estimated that by the year 2050 more than 5 million Americans will have AF.3 Obesity is clearly associated with increased prevalence of hypertension, coronary artery disease, diabetes mellitus, left ventricular hypertrophy, left atrial enlargement, and congestive heart failure.4-5 In turn, hypertension, left atrial enlargement, and congestive heart failure are all thought to be important contributors to the development of AF.3, 6 Recently, obstructive sleep apnea, which occurs in about 40% of obese individuals, has been found to be strongly associated with AF.7 Despite these biological links, a clear association between obesity and risk of AF has not been established.
In this issue of JAMA, Wang . . . [Full Text of this Article]
Author Affiliation: Clinical Electrophysiology Section, Columbia University Medical Center, New York, NY.
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