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Coronary artery disease means narrowing of the coronary arteries (arteries that supply blood to the heart). This narrowing is due to a buildup in the walls of the arteries of plaque (deposits made up of cholesterol, other fats, and calcium)—a process called atherosclerosis (hardening of the arteries). If a plaque becomes delicate and breaks, a blood clot will quickly form that can block blood flow in the artery and may lead to a myocardial infarction (death of the heart muscle area supplied by the blocked artery), often referred to as a heart attack. The November 24, 2004, issue of JAMA includes an article about coronary artery disease.

SYMPTOMS

• Coronary artery disease can develop slowly without any symptoms.
  
• Angina—chest pain that can radiate to (or sometimes is limited to) the shoulders, arms, or jaw. Angina usually lasts several minutes and may be related to activity, exercise, large meals, cold, or . . . [Full Text of this Article]

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