This Article  • Full text  • PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (2)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Topic Collections  • Surgical Interventions  • Cardiovascular/ Cardiothoracic Surgery  • Cardiovascular Intervention  • Revascularization  • Alert me on articles by topic

Works in Progress

David R. Holmes, Jr, MD

JAMA. 2004;292:2777-2778.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Interventional cardiology has a long and rich tradition of randomized clinical trials, the results of which have dramatically improved patient care. In the past few years, attention has particularly focused on drug-eluting stents, which have quickly become predicate devices (ie, against which new stents are compared). In the case of sirolimus-eluting stents, device approval was based in large measure on the 2 initial randomized clinical trials of RAVEL¹ and SIRIUS.² Based on the dramatic improvement in reducing restenosis with these devices demonstrated in these 2 trials, patients and physicians alike have embraced this new technology and physicians have used drug-eluting stents in subsets of patients for whom the data from trials were very limited. Early randomized trials of any device or drug typically target restricted "ideal" patient groups; this was certainly the case with the early drug-eluting stent trials. An important subset of patients that . . . [Full Text of this Article]

Author Affiliation: Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn.

RELATED ARTICLE

Sirolimus-Eluting vs Uncoated Stents for Prevention of Restenosis in Small Coronary Arteries: A Randomized Trial
Diego Ardissino, Claudio Cavallini, Ezio Bramucci, Ciro Indolfi, Antonio Marzocchi, Antonio Manari, Giulia Angeloni, Giuseppe Carosio, Erminio Bonizzoni, Stefania Colusso, Monica Repetto, Piera Angelica Merlini, and for the SES-SMART Investigators
JAMA. 2004;292(22):2727-2734.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels
Mehilli et al.
Eur Heart J 2006;27:260-266.
ABSTRACT | FULL TEXT  

Sirolimus-Eluting Stents for Small Vessels
Journal Watch Cardiology 2005;2005:2-2.
FULL TEXT