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In Reply: In response to Dr Kaisers and colleagues, there had been only 2 other large published studies of inhaled nitric oxide in patients with ARDS.^1-2 The first of these studies was halted early. It enrolled only patients who increased their oxygenation status when challenged with inhaled nitric oxide prior to enrollment. In that trial, the number of patients with improved signs of acute lung injury was not statistically different between the 2 treatment groups, the primary end point of the trial. The design of our 2 trials was different in that all patients were randomized and response status was not established. Our first study was a phase 2 study that was designed to ascertain safety and potentially link a dose effect to clinical outcome in patients with ARDS. A post-hoc analysis suggested that there was a clinical benefit of inhaled nitric oxide at 5 ppm among this group of . . . [Full Text of this Article]

R. Phillip Dellinger, MD
dellinger-phil@cooperhealth.edu
Robert Wood Johnson Medical College/UMDNJ
Cooper University Hospital
Camden, NJ

Robert W. Taylor, MD
St Louis University
St John's Mercy Medical Center
St Louis, Mo

Janice L. Zimmerman, MD
Baylor College of Medicine
Ben Taub General Hospital
Houston, Tex

Richard C. Straube, MD
INO Therapeutics Inc
Clinton, NJ
For the Inhaled Nitric Oxide in ARDS Study Group

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