This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Women's Health, Other  • Oncology  • Breast Cancer  • Alert me on articles by topic

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: In their editorial about the WHI study, Drs Hulley and Grady¹ stated that "Given the absence of evidence in all 3 trials [HERS and both segments of WHI] that these hormone regimens prevent CHD in these populations..., it is now clear that the previously available evidence was misleading." I am puzzled at this conclusion, as the HERS trial was not a preventive study; participants had to meet strict criteria for coronary vascular disease. Thus, that trial only showed that hormone therapy is not an effective treatment for CHD. Similarly, it is not clear how many participants in the WHI were free of disease. Since CHD is a chronic process and takes years to develop, it is very likely that many of the 66% of women in the estrogen and progestin segment of WHI aged 60 years or older had significant disease but were asymptomatic.²

Hulley and Grady . . . [Full Text of this Article]

Katherine L. Brubaker, MD
katebru@meer.net
The Permanente Medical Group
Santa Clara, Calif

RELATED ARTICLES

Effects of Estrogen-Only Treatment in Postmenopausal Women
Herbert Kuhl
JAMA. 2004;292(6):683.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Matti A. Rookus and Flora E. van Leeuwen
JAMA. 2004;292(6):683.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Vicki F. Meyer
JAMA. 2004;292(6):683-684.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Valerie Beral, Emily Banks, and Gillian Reeves
JAMA. 2004;292(6):684.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Carlo Campagnoli, Chiara Abbà, Simona Ambroggio, and Clementina Peris
JAMA. 2004;292(6):684.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Karla Kerlikowske and Diana L. Miglioretti
JAMA. 2004;292(6):684-685.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Frank A. Perlroth
JAMA. 2004;292(6):685.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Michael H. Cooper
JAMA. 2004;292(6):685.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women—Reply
Garnet L. Anderson
JAMA. 2004;292(6):685-686.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women—Reply
Stephen B. Hulley and Deborah Grady
JAMA. 2004;292(6):686-687.
EXTRACT | FULL TEXT  

The WHI Estrogen-Alone Trial—Do Things Look Any Better?
Stephen B. Hulley and Deborah Grady
JAMA. 2004;291(14):1769-1771.
EXTRACT | FULL TEXT  

Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women: The Women's Health Initiative Randomized Trial
Rowan T. Chlebowski, Susan L. Hendrix, Robert D. Langer, Marcia L. Stefanick, Margery Gass, Dorothy Lane, Rebecca J. Rodabough, Mary Ann Gilligan, Michele G. Cyr, Cynthia A. Thomson, Janardan Khandekar, Helen Petrovitch, and Anne McTiernan
JAMA. 2003;289(24):3243-3253.
ABSTRACT | FULL TEXT  

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators
JAMA. 2002;288(3):321-333.
ABSTRACT | FULL TEXT  

Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk
Catherine Schairer, Jay Lubin, Rebecca Troisi, Susan Sturgeon, Louise Brinton, and Robert Hoover
JAMA. 2000;283(4):485-491.
ABSTRACT | FULL TEXT