This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Oncology  • Breast Cancer  • Women's Health, Other  • Alert me on articles by topic

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: Dr Brubaker suggests that the failure to find that postmenopausal hormone therapy prevented CVD events in participants from WHI and HERS was due to the presence of prior coronary artery disease in many of the women. The evidence from the clinical trials, however, does not support this belief. Estrogen-plus-progestin caused a greater and more prolonged increase in risk of coronary events in WHI than in HERS, even though overt prior coronary disease was rare in WHI and universal in HERS participants. Subgroup analyses did not reveal benefit among women in WHI who did not have prior CVD^1-2 or its risk factors.² Women in the youngest age group (aged 50-59 years) who were given estrogen alone had a somewhat lower risk of CVD events than those who received placebo,¹ but the possible age interaction was not statistically significant nor was there a similar trend in the estrogen-plus-progestin trial.²

On . . . [Full Text of this Article]

Stephen B. Hulley, MD, MPH
shulley@psg.ucsf.edu

Deborah Grady, MD, MPH
Department of Epidemiology and Biostatistics
University of California, San Francisco

RELATED ARTICLES

Effects of Estrogen-Only Treatment in Postmenopausal Women
Herbert Kuhl
JAMA. 2004;292(6):683.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Matti A. Rookus and Flora E. van Leeuwen
JAMA. 2004;292(6):683.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Vicki F. Meyer
JAMA. 2004;292(6):683-684.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Valerie Beral, Emily Banks, and Gillian Reeves
JAMA. 2004;292(6):684.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Carlo Campagnoli, Chiara Abbà, Simona Ambroggio, and Clementina Peris
JAMA. 2004;292(6):684.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Karla Kerlikowske and Diana L. Miglioretti
JAMA. 2004;292(6):684-685.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Frank A. Perlroth
JAMA. 2004;292(6):685.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Michael H. Cooper
JAMA. 2004;292(6):685.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women—Reply
Garnet L. Anderson
JAMA. 2004;292(6):685-686.
EXTRACT | FULL TEXT  

Effects of Estrogen-Only Treatment in Postmenopausal Women
Katherine L. Brubaker
JAMA. 2004;292(6):686.
EXTRACT | FULL TEXT  

Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy: The Women's Health Initiative Randomized Controlled Trial
The Women's Health Initiative Steering Committee
JAMA. 2004;291(14):1701-1712.
ABSTRACT | FULL TEXT