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To the Editor: Metabolic abnormalities in type 2 diabetes are associated with increased platelet sensitivity to proaggregants and decreased platelet sensitivity to endogenous antiaggregants.^1-2 Thus, patients with type 2 diabetes have an increased risk of developing atherosclerosis and cardiovascular complications.²

Consumption of tomato products has been found to be inversely correlated with incidence of acute coronary events, development of early atherosclerosis, and mortality from heart disease.³ Furthermore, clarified tomato juice has been shown to inhibit human platelet aggregation in vitro^4-5 and in an animal model.⁶ We examined whether consumption of tomato juice clarified by filtration could inhibit platelet aggregation in patients with type 2 diabetes or impaired glucose tolerance.

Methods

Patients with type 2 diabetes (n = 18) or impaired glucose tolerance (n = 2) without prior history of thromboembolic events were recruited from the community using media advertising. Fourteen men and 6 women aged 43 to 82 years with a . . . [Full Text of this Article]

Sheryl A. Lazarus, BS
Department of Nutrition and Dietetics
Faculty of Health
University of Newcastle

Kerry Bowen, PhD, FRACP
Diabetes Education Centre
Royal Newcastle Hospital

Manohar L. Garg, PhD, APD
manohar.garg@newcastle.edu.au
Department of Nutrition and Dietetics
Faculty of Health
University of Newcastle
Newcastle, Australia

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