This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (7)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Pediatrics  • Adolescent Medicine  • Psychiatry  • Depression  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

Contributions of a Major Trial

Richard M. Glass, MD

JAMA. 2004;292:861-863.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The publication of the results of the Treatment for Adolescents With Depression Study¹ (TADS) in this issue of JAMA is certainly timely in view of recent and widely publicized controversies regarding treating adolescents with depression.^2-4 Beyond that, these results shed new light on some older controversies about psychiatric treatments. As is usually the case with good research, the study provides important answers but also raises several important questions.

In the TADS study, a randomized controlled trial funded by the National Institute of Mental Health and conducted at 13 academic and community centers in the United States, 429 patients aged 12 to 17 years (mean age, 15 years), who had a primary diagnosis of major depressive disorder, provided written informed consent (along with consent from at least one of their parents) to participate in the study. Participants on average had moderate to severe symptom levels based on . . . [Full Text of this Article]

Author Affiliations: Dr Glass is Deputy Editor, JAMA, and is with the Department of Psychiatry, Pritzker School of Medicine, University of Chicago, Chicago, Ill.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Treatment for Adolescents With Depression Study (TADS): Long-term Effectiveness and Safety Outcomes
The TADS Team
Arch Gen Psychiatry 2007;64:1132-1143.
ABSTRACT | FULL TEXT  

Commentary: The Psychological Impact of Pediatric Cancer Hardiness, the Exception or the Rule?
Noll and Kupst
J Pediatr Psychol 2007;32:1089-1098.
FULL TEXT  

Posttraumatic Stress and Depressive Symptoms, Alcohol Use, and Recurrent Traumatic Life Events in a Representative Sample of Hospitalized Injured Adolescents and Their Parents
Zatzick et al.
J Pediatr Psychol 2006;31:377-387.
ABSTRACT | FULL TEXT  

Journal Watch
Arch. Dis. Child. 2005;90:106-107.
FULL TEXT  

Trial Registration: A Great Idea Switches From Ignored to Irresistible
Rennie
JAMA 2004;292:1359-1362.
FULL TEXT  

Fluoxetine plus CBT Effective for Major Depressive Disorder in Adolescents
JWatch Pediatrics 2004;2004:4-4.
FULL TEXT