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Tracy Hampton, PhD

JAMA. 2005;293:1180.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Most people know consuming fatty foods can have negative health effects. Now, researchers studying rats and mice have identified the molecular mechanism by which saturated and trans-fats trigger a rise in blood cholesterol and triglycerides, increasing the risk of cardiovascular disease (Lin et al. Cell. 2005;120:261-273).

The molecular players in this scenario are also found in humans. Although it remains to be seen whether the results will have clinical relevance, pharmaceutical companies have already expressed interest in the implications of the new findings for treating individuals with elevated blood cholesterol levels.

Scientists are gaining insights into how foods rich in saturated and trans-fats trigger a rise in blood cholesterol and triglycerides. (Photo credit: Ted Grudzinski/AMA)

The researchers, Bruce Spiegelman, PhD, and colleagues at the Dana-Farber Cancer Institute, in Boston, found that saturated and trans-fats in the diet induce a molecule called PPAR-coactivator-1. . . [Full Text of this Article]

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