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To the Editor: The CAMELOT study¹ did not appear to consider the effect of alcohol consumption on the development of coronary artery disease. Alcohol consumption has been shown to be inversely related to the severity of angiographically determined coronary artery disease.^2-3 The risk of extensive coronary calcification is lower in individuals who consume light to moderate amounts of ethanol than in nondrinkers.⁴ Thus, alcohol consumption might have been a confounder in this study.

Luca Mascitelli, MD
lumasci@libero.it
Comando Brigata alpina "Julia"
Udine, Italy

Francesca Pezzetta, MD
Ospedale San Michele
Gemona del Friuli, Italy

1. Nissen SE, Tuzcu EM, Libby P, et al, CAMELOT Investigators. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial. JAMA. 2004;292:2217-2226. FREE FULL TEXT 2. Handa K, Sasaki J, Saku K, Kono S, Arakawa K. Alcohol consumption, serum lipids and severity of angiographically determined coronary artery disease. Am J Cardiol. 1990;65:287-289. FULL TEXT | ISI | PUBMED 3. Liu Y, Tanaka H, Sasazuki S, et al. Alcohol consumption and severity of angiographically determined coronary artery disease in Japanese men and women. Atherosclerosis. 2001;156:177-183. FULL TEXT | ISI | PUBMED 4. Vliegenthart R, Oei HH, van den Elzen AP, et al. Alcohol consumption and coronary calcification in a general population. Arch Intern Med. 2004;164:2355-2360. FREE FULL TEXT

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293:1188.

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