 |
|
Smoking While Pregnant
Transplacental Mutagenesis of the Fetus by Tobacco Smoke
David M. DeMarini, PhD;
R. Julian Preston, PhD
JAMA. 2005;293:1264-1265.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
The International Agency for Research on Cancer (IARC) has identified tobacco smoking as the cause of cancer at more organ sites (11) than any other human carcinogen.1 Eight of these organ sites have been examined for smoking-associated genotoxic effects, and such effects have been found in all 8 sites.2 The sites are the oral/nasal cavity, esophagus, pharynx/larynx, lung, pancreas, myeloid organs, bladder/ureter, and uterine cervix. To this long list of organs in adults in which tobacco smoking causes genotoxic effects might now be added the somatic epithelial cells of fetuses carried by mothers who smoke. As described by de la Chica and colleagues3 in this issue of JAMA, smoking during pregnancy was reported to be associated with increased chromosomal instability in amniocytes collected by amniocentesis. Such results, if substantiated, would provide direct evidence of tobacco-associated intrauterine mutagenesis and could have important . . . [Full Text of this Article]
Author Affiliations: Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC.
RELATED ARTICLE
Chromosomal Instability in Amniocytes From Fetuses of Mothers Who Smoke
Rosa Ana de la Chica, Isabel Ribas, Jesús Giraldo, Josep Egozcue, and Carme Fuster
JAMA. 2005;293(10):1212-1222.
ABSTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Macaque Trophoblast Migration toward RANTES Is Inhibited by Cigarette Smoke-Conditioned Medium
Thirkill et al.
Toxicol Sci 2006;91:557-567.
ABSTRACT
| FULL TEXT
|
