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Tracy Hampton, PhD

JAMA. 2005;293:1309-1310.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To spur healing following an injury, many genes are called into action to promote matrix remodeling, cell motility, and angiogenesis. While these processes are all well and good for the recruitment of blood, cells, and nutrients needed to repair damaged tissue, they can be hijacked by tumors to promote malignant invasion and metastasis.

"There are a lot of interesting parallels between cancer progression and the normal process of wound healing," said Patrick Brown, MD, PhD, of the Stanford University School of Medicine, in Stanford, Calif.

Brown and his research team have found that a relationship between cancer progression and what they call a "wound-response gene signature" can be used to predict clinical outcomes in some patients. The scientists analyzed genetic and survival data from breast cancer patients and discovered that those whose tumors expressed this gene signature were less likely to be alive in 10 years and . . . [Full Text of this Article]

SIGNATURE DESIGN