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In Reply: Dr Staessen raises the point that the number of incident events in our study was small and the comparisons may have had inadequate power to detect differences in effects. For persons who were at low risk for cardiovascular disease death by virtue of no history of cardiovascular disease and no diabetes, the overall P value for differences in treatment effects was .002 for comparison of combination therapy groups, the main focus of our article. That the number of events was small supports our assertion that these findings pertain to patients with hypertension but without other complications who are at lower risk than are those with a history of cardiovascular disease. In the case of the CCB plus ACE inhibitor group, we acknowledge that the number of women using this combination is small and caution is urged in interpretation. However, our main concern was with diuretic combinations.

The hazard . . . [Full Text of this Article]

Sylvia Wassertheil-Smoller, PhD
smoller@aecom.yu.edu
Albert Einstein College of Medicine
Bronx, NY

Bruce Psaty, MD, PhD
University of Washington
Seattle

Philip Greenland, MD
Northwestern University
Chicago, Ill

Albert Oberman, MD, MPH
University of Alabama at Birmingham

Theodore Kotchen, MD
Medical College of Wisconsin
Milwaukee

Charles Mouton, MD
Howard University College of Medicine
Washington, DC

Henry Black, MD
Fred Hutchinson Cancer Research Center
Seattle, Wash

Aaron Aragaki
University of Buffalo
Buffalo, NY

Maurizio Trevisan, MD, MS
Rush University Medical Center
Chicago, Ill

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