 |
|
Diuretics Are Color Blind
James D. Neaton, PhD;
Lewis H. Kuller, MD
JAMA. 2005;293:1663-1666.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is considered one of the most important recent clinical trials in hypertension. This mega-trial was motivated by (1) the observation that trials of participants with diastolic blood pressure (BP) in the range of 90 to 114 mm Hg did not result in as large a reduction in coronary heart disease (CHD) incidence as the epidemiologic data suggested should be the case; (2) different classes of antihypertensive drugs were thought to have fewer adverse effects (eg, decreased levels of serum potassium, increased levels of blood glucose and blood cholesterol and triglycerides) than diuretics, and these adverse effects might explain the lower than expected effect on CHD of a diuretic-based BP-lowering treatment; and (3) newer agents that had potentially favorable mechanisms of action might provide benefit above and beyond BP control.1-2 The high . . . [Full Text of this Article]
Author Affiliations: Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (Dr Neaton); and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (Dr Kuller).
RELATED ARTICLE
Outcomes in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone, Amlodipine, and Lisinopril
Jackson T. Wright, Jr, J. Kay Dunn, Jeffrey A. Cutler, Barry R. Davis, William C. Cushman, Charles E. Ford, L. Julian Haywood, Frans H. H. Leenen, Karen L. Margolis, Vasilios Papademetriou, Jeffrey L. Probstfield, Paul K. Whelton, Gabriel B. Habib, and for the ALLHAT Collaborative Research Group
JAMA. 2005;293(13):1595-1608.
ABSTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Have ALLHAT, ANBP2, ASCOT-BPLA, and So Forth Improved Our Knowledge About Better Hypertension Care?
Sawicki and McGauran
Hypertension 2006;48:1-7.
FULL TEXT
Diuretics for Hypertension
Krakoff
Circulation 2005;112:e127-e129.
FULL TEXT
|
