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Bridget M. Kuehn

JAMA. 2005;293:2200-2201.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The way to solving the obesity problem may be through the gut, or at least through the hormones that emanate from it, according to evidence about the crucial role gut hormones play in regulating appetite and body weight.

The gut plays a much larger role in regulating appetite, body weight, and metabolism than scientists had previously suspected.

In a review summarizing 20 years of research on gut hormones, researchers highlight the role of such hormones in maintaining energy balance and how they might be exploited for the development of obesity treatments (Badman and Flier. Science. 2005;307:1909-1911). This organ, research has revealed, has a highly redundant system of endocrine and neurological signals.

"The gut is playing a much bigger role in regulating appetite, body weight, and metabolism than we knew before," Jeffrey S. Flier, MD, a professor of medicine at Beth Israel Deaconess Medical Center in Boston.

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BATTLING THE BULGE