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To the Editor: The Clinical Review by Dr Sink and colleagues¹ erroneously presents the results of one of the cited studies.² On page 602, the article states " . . . the intention-to-treat analysis found only the 16-mg/d dose to be significantly better than placebo . . . with no benefit for the other doses," using the Neuropsychiatric Inventory as the outcome. In fact, both the 16-mg/d and the 24-mg/d galantamine doses were found to be significantly better than placebo for the Neuropsychiatric Inventory as well as for all other outcome measures.²

Financial Disclosures: Dr Tariot receives grant support from Janssen.

Pierre N. Tariot, MD
pierre_tariot@urmc.rochester.edu
Department of Psychiatry
Monroe Community Hospital
Rochester, NY

1. Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA. 2005;293:596-608. FREE FULL TEXT 2. Tariot PN, Solomon PR, Morris JC, et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD: the Galantamine USA-10 Study Group. Neurology. 2000;54:2269-2276. FREE FULL TEXT

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293:2212.

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