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In Reply: Thank you to all who responded to the joint editorial published by the ICMJE. I respond only for myself to the 3 authors whose representative letters appear in this issue of JAMA.

Ms Dresser addresses the advantage of a comprehensive trial registry in raising public awareness that the purpose of clinical research is to advance knowledge, not to provide the best treatment for participants. I submit that the raised public awareness and the occasional successful treatment of patients who volunteer for such studies are both secondary but welcome outcomes of a clinical trial registry.

Publishing trials with negative results, as suggested by Dr Khalil and colleagues, is sound only if the trials are themselves scientifically sound. The commitment to publish scientifically sound clinical trials with negative (and positive) results is implicit in the call for registration.

The suggestion by Dr Besselink and colleagues to publish full study . . . [Full Text of this Article]

Catherine D. DeAngelis, MD, MPH
Editor-in-Chief, JAMA

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