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Fetal Loss Associated With Excess Thyroid Hormone Exposure—Reply
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In Reply: The scoring of miscarriages in our retrospective study was consistent with that used in the obstetric literature.1 There was a paucity of confounding risk factors because all 3 major groups belong to the same extended family, live on the same small island, consume the same diet, and have equal access to the same medical care. Other risk factors such as parental age, parity, smoking habits, and the coexistence of chronic diseases were assessed and controlled for in the statistical analysis.
Our study shows that the complications of higher miscarriage rate and intrauterine growth retardation, previously known to be associated with hyperthyroidism during pregnancy,2 occur even when the hormone excess does not affect maternal tissues. The 2 study groups of affected mothers and affected fathers are ideally matched. There were no other known causes for intrauterine growth retardation.
Regarding reduced birth weights, a recent study of isolated fetal hyperthyroidism . . . [Full Text of this Article]
Samuel Refetoff, MD
refetoff@uchicago.edu
Departments of Medicine and Pediatrics
Roy E. Weiss, MD, PhD
Department of Medicine
University of Chicago
Chicago, Ill
João Anselmo, MD
Endocrinology Unit
Hospital Divino Espirito Santo
Ponta Delgada, Azores-Portugal
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