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To the Editor: The Brief Report by Dr Larsson and colleagues¹ concluded that magnesium intake was inversely associated with the risk of developing colorectal cancer in women. In estimating the magnesium intake, food content of this metal ion appears to have been appropriately measured. However, the content of magnesium in local drinking water was not assessed. Variations of the magnesium content of water in the geographical area that was investigated are considerable.²

Data from the official GVB groundwater database registry in the Geological Survey of Sweden (Sveriges geologiska undersökning [SGU], Uppsala), the Swedish Water and Wastewater Association³ and SGU,^4-5 and the city of Uppsala indicate that mean magnesium concentrations of drinking water vary between 1 and 20 mg/L, with occasional values reaching 40 mg/L in the studied area. Given that the association between magnesium intake and incidence of colorectal cancer reflected differences in magnesium intake of 50 to 100 . . . [Full Text of this Article]

Lars Wiklund, MD, PhD
lars.wiklund@akademiska.se
Department of Anesthesiology and Intensive Care Medicine
Uppsala University

Jan Pousette, PhD
Geological Survey of Sweden

Mary George, MD, PhD
Department of Anesthesiology and Intensive Care Medicine
Uppsala University Hospital
Uppsala, Sweden

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