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Global, Regional, and Future Perspectives

Vincent Quagliarello, MD

JAMA. 2005;293:3061-3062.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Contemporary case series describing patterns of infective endocarditis date back to the Gulstonian Lectures of Osler, in which he described clinical complications, pathogenesis, and pathological features.¹ With diagnostic and treatment advances over the past 50 years, recent descriptions have focused on the broad spectrum of microbial causes, an increasing array of predisposing risks, the role of bactericidal antibiotic combinations, and the impact of valve surgery on clinical outcome.^2-5 Nonetheless, epidemiologic shifts of incidence and bacterial etiologies have been suspected because of advancing technological intervention, global antimicrobial resistance, and changing health care delivery patterns.⁶

In this issue of JAMA, 2 studies^7-8 reveal distinct community and global perspectives of temporal trends in infective endocarditis. Both studies were rigorously carried out, with appropriate and clearly defined case inclusion criteria, baseline variable assessment, outcome determination, and analytical methods. In the report by Tleyjeh et al,⁷ investigators evaluated a population-based cohort . . . [Full Text of this Article]

Author Affiliation: Yale University School of Medicine, New Haven, Conn.

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