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M. J. Friedrich

JAMA. 2005;293:409-410.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

San Diego—Although most cases of Parkinson disease (PD) are believed to result from some combination of genetic susceptibility and environmental exposures, much about how these factors conspire to destroy dopaminergic neurons remains elusive. New insights into the factors that give rise to PD and ways to counteract their effects are increasing the understanding of the disease and revealing novel approaches for treatment.

Loss of dopaminergic neurons results in reduced dopamine uptake (yellow) in patients with Parkinson disease compared with healthy controls. (Image from Arch Neurol. 2004;61:919-925.)

At the 2004 annual meeting of the Society for Neuroscience, held here in October, researchers described increasing evidence for the role of a common pesticide and related compounds in the development of PD. They also discussed how such interventions as exercise and cyclooxygenase 2 (COX-2) inhibitors might address oxidation damage to dopaminergic neurons.

STRONGER PESTICIDE LINK

Epidemiological evidence suggests that occupational exposure . . . [Full Text of this Article]

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