 |
|
Predictors of Lack of Improvement After Thrombolytic Stroke Therapy—Reply
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In Reply: Dr Pastewski and colleagues would like more information on patients treated with alteplase after 3 hours. In our study, no patient received alteplase less than 60 minutes before or 270 minutes after onset of symptoms. Of the 40 patients (18%) who received alteplase after 3 hours, 20 (50%) had a poor outcome (modified Rankin scale  3) at 90 days. The study was not powered to demonstrate a statistically significant difference in outcome at 90 days between patients that received alteplase within or outside the 3-hour window.
Time from symptom onset to treatment with alteplase was an independent predictor of lack of improvement at 24 hours. When time to treatment is analyzed as a categorical variable, lack of improvement was significantly more likely in patients who had been treated after the 3-hour window (68% vs 51%, P = .048). In logistic regression analysis, treatment after 3 hours was a predictor . . . [Full Text of this Article]
Gustavo Saposnik, MD, MSc
gsaposni@uwo.ca
Bryan Young, MD, FRCPC;
Vladimir Hachinski, MD, FRCPC
Stroke Program, London Health Sciences Center
University of Western Ontario
London
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLES
Predictors of Lack of Improvement After Thrombolytic Stroke Therapy
Andrew Pastewski, Yizhak Kupfer, and Sidney Tessler
JAMA. 2005;293(4):421.
EXTRACT
| FULL TEXT
Lack of Improvement in Patients With Acute Stroke After Treatment With Thrombolytic Therapy: Predictors and Association With Outcome
Gustavo Saposnik, Bryan Young, Brian Silver, Silvia Di Legge, Fiona Webster, Vadim Beletsky, Vivek Jain, Yongchai Nilanont, and Vladimir Hachinski
JAMA. 2004;292(15):1839-1844.
ABSTRACT
| FULL TEXT
|
