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Dementia and Testosterone Levels in Men—Reply
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In Reply: Dr Daniell raises possible confounders of the results of our study that demonstrated an inverse relationship between brain levels of testosterone and development of AD. Although we were unable to directly control for obesity, we believe that the contribution of an association with low testosterone to our observations is minimal. Obesity is also associated with elevated estradiol levels and we observed no significant relationship between brain levels of estradiol and neuropathological status. We also do not think that expectant care and opioid use as features of the agonal state explain our results. While it is likely that agonal state may significantly differ between individuals with and without AD, our design indirectly controlled for this possibility with the use of a third group, men with mild neuropathological changes who also showed low levels of testosterone. We reason that because death in this group was unrelated to neurological disease, agonal . . . [Full Text of this Article]
Christian J. Pike, PhD
cjpike@usc.edu
Andrus Gerontology Center
Emily R. Rosario, MS
Neuroscience Graduate Program
Frank Z. Stanczyk, PhD
Department of Obstetrics and Gynecology
University of Southern California
Los Angeles
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