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Phil B. Fontanarosa, MD; Catherine D. DeAngelis, MD, MPH

JAMA. 2005;293:866-867.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Innovations and discoveries in biotechnology are revolutionizing medical research. Recent advances in molecular biology, proteomic technologies, genomic applications, cellular and tissue engineering, computational methods, and bioengineering and bioimaging techniques have markedly accelerated the pace of medical research and have created unprecedented opportunities for progress in medical science.

This theme issue of JAMA illustrates the promise and potential of biotechnology in medicine, with reports that demonstrate cutting-edge advances and novel discoveries in several rapidly evolving areas of medical research. In 2 studies on cancer detection, Casey and colleagues¹ demonstrate that conversion analysis increases the diagnostic yield of germline mutations in colorectal cancer compared with conventional genomic sequencing, while Grossman and colleagues² report that a proteomic assay may be a useful adjunct to cystoscopy for detecting bladder cancer. The elegant study by Nettles and colleagues³ using an ultrasensitive genotyping assay to detect drug . . . [Full Text of this Article]

Author Affiliations: Dr Fontanarosa is Executive Deputy Editor and Dr DeAngelis is Editor-in-Chief, JAMA.