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edited by David Castle and Robin Murray, 218 pp, with illus, $80, ISBN 0-521-81940-7, New York, NY, Cambridge University Press, 2004.

JAMA. 2005;293:1008-1009.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Unlike the majority of books recently published on marijuana, which focus on prevalence, legality, and therapeutic utility, Marijuana and Madness takes a rigorous scientific look at the relationship of marijuana to cognition and mental illness. It provides a contemporary appraisal of cannabis research that neuroscientists and clinicians will find invaluable. While conferring legitimacy, the density and detail of information place the book beyond the scope of the nonmedical reader.

The first chapter outlines the neurochemistry of the biologically active exogenous and endogenous cannabinoids. The plant Cannabis sativa and the endocannabinoid anandamide (from the Sanskrit for bliss) receive primary emphasis. The second chapter describes the neuroanatomical distribution of the cannabinoid 1 (CB1) receptor, its proposed functions, and its physiology. The significant effect of cannabis on short-term memory and the hypothalamic control of appetite, including the antiobesity potential of the CB1 antagonist rimonabant, are also covered.

Chapter 3 reviews the psychomimetic . . . [Full Text of this Article]

Shahla Modir, MD, Reviewer
UCLA Neuropsychiatric Institute
smodir@mednet.ucla.edu

John Tsuang, MD, Reviewer
Harbor-UCLA Medical Center
johntsuang@yahoo.com

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