 |
|
Surveillance of BRCA1 and BRCA2 Carriers—Reply
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In Reply: We agree with Dr Helvie that the fact that most of the patients in our study received previous mammography but not MRI could artificially increase the difference in sensitivity between MRI and mammography observed in the first round of screening (85% vs 38%). However, since the performance of the data analysis on which our article was based, most of the patients in the published cohort have had 1 or 2 additional rounds of screening. There have been 7 additional cancers identified in this cohort (1 on screen 2, 3 on screen 4, and 3 on screen 5); all 7 were detected by screening MRI but only 2 were detected by screening mammography. Therefore, of the total of 16 incident cancers, 13 (81%) were detected by MRI and 5 (31%) by mammography. These findings are almost identical with those in a recent update of the Dutch National Study.1
. . . [Full Text of this Article]
Ellen Warner, MD
ellen.warner@sw.ca
Department of Medicine
Roberta Jong, MD
Department of Medical Imaging
Donald Plewes, PhD;
Martin Yaffe, PhD
Imaging Research and Department of Medical Biophysics
Steven Narod, MD
Center for Research in Women’s Health
Sunnybrook and Women’s College Health Sciences Centre
Toronto, Ontario
RELATED ARTICLES
Surveillance of BRCA1 and BRCA2 Carriers
Mark Helvie
JAMA. 2005;293(8):931.
EXTRACT
| FULL TEXT
Surveillance of BRCA1 and BRCA2 Mutation Carriers With Magnetic Resonance Imaging, Ultrasound, Mammography, and Clinical Breast Examination
Ellen Warner, Donald B. Plewes, Kimberley A. Hill, Petrina A. Causer, Judit T. Zubovits, Roberta A. Jong, Margaret R. Cutrara, Gerrit DeBoer, Martin J. Yaffe, Sandra J. Messner, Wendy S. Meschino, Cameron A. Piron, and Steven A. Narod
JAMA. 2004;292(11):1317-1325.
ABSTRACT
| FULL TEXT
|
