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Neurodevelopmental Impairment and Neonatal Infections—Reply
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In Reply: We were indeed surprised that bloodstream infections with coagulase-negative staphylococci, often considered low-virulence organisms, were associated with subsequent adverse outcomes in ELBW infants and agree that these infants should be included in therapeutic trials. In contrast, ELBW infants with culture-negative clinical infection represent a spectrum of clinical disease ranging from relatively mild to very severe illness; thus, adverse outcomes in this group are less surprising. We did not collect information on pneumonia.
Because our article focused on neonatal sepsis, we did not present data on infants who had NEC without prior, concurrent, or subsequently proven sepsis. In the cohort studied, 180 infants had NEC without sepsis (116 medical NEC and 64 surgical NEC). By bivariate analysis, infants with NEC without sepsis were more likely than those who were uninfected (no sepsis, meningitis, clinical infection, or NEC) to have a mental development index or psychomotor development index score of . . . [Full Text of this Article]
Barbara J. Stoll, MD
Emory University School of Medicine
Atlanta, Ga
Nellie Hansen, MPH
Research Triangle Institute
Research Triangle Park, NC
for the National Institute of Child Health and Human Development Neonatal Research Network
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