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Never, Now, or in the Future?

Catherine E. DuBeau, MD

JAMA. 2005;293:998-1001.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Deciding whether to treat postmenopausal women with urinary incontinence (UI) with estrogen has become increasingly difficult. The literature is divided but generally supportive. A Cochrane systematic review concluded that "estrogen treatment can improve or cure incontinence," especially urge UI.¹ Similarly, the International Consultation on Incontinence agreed in 2004 that "it seems reasonable to assume that estrogen therapy may be of benefit for the irritative symptoms of urinary urgency, frequency, and urge UI," but noted that estrogen had little role in the treatment of stress UI.²

However, in the Cochrane combined meta-analyses of randomized controlled trials, the overall number of participants was small (for example, for the outcome of subjective cure and improvement of UI, the analysis included 179 women assigned to estrogen and 177 women assigned to placebo from a total of 9 trials).¹ Although the large prospective Heart and Estrogen/Progestin Replacement Study (HERS) (n = 1525) found . . . [Full Text of this Article]

Author Affiliation: Section of Geriatrics, University of Chicago, Chicago, Ill.

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