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Homocysteine and Fracture Prevention
Joyce B. J. van Meurs, PhD;
André G. Uitterlinden, PhD
JAMA. 2005;293:1121-1122.
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Osteoporotic fractures are a major health problem in Western society and are associated with increased morbidity and mortality and substantial economic costs.1 Because the number of fractures will increase throughout the world as the population ages, prevention of fractures is becoming increasingly important. Recently, studies have identified a new and potentially modifiable risk factor for osteoporotic fracture—a mildly elevated circulating homocysteine level.2-3 These epidemiological studies showed that a relatively high homocysteine level predicts a higher fracture risk but they did not establish a causal relationship. The question remained whether the increase in fracture risk was due to homocysteine itself, or to other covarying factors.
To establish a causal relationship between elevated homocysteine concentrations and osteoporosis, data from 2 types of studies are needed. One consists of randomized placebo-controlled trials studying the effect of lowering homocysteine levels on the incidence of . . . [Full Text of this Article]
Author Affiliations: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
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