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Challenges and Opportunities in Cancer Prevention

Eric J. Jacobs, PhD; Michael J. Thun, MD

JAMA. 2005;294:105-106.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

This issue of JAMA includes 2 articles from the Women’s Health Study (WHS).^1-2 This 10-year long, placebo-controlled, randomized trial of low-dose aspirin and vitamin E included nearly 40 000 predominantly middle-aged women with no history of cancer or cardiovascular disease.³ The WHS used a 2 x 2 factorial design to evaluate the effects of low-dose aspirin (100 mg) taken every other day and 600 IU of vitamin E (in the form of natural-source -tocopherol), also taken every other day. Neither alternate-day, low-dose aspirin nor vitamin E showed any evidence of efficacy in reducing overall cancer incidence or mortality.^1-2 With respect to noncancer outcomes, notable findings for low-dose aspirin included a reduction in stroke risk, no apparent effect on myocardial infarction, and an increased risk of gastrointestinal bleeding requiring transfusion.⁴ Vitamin E had no apparent effect on either cardiovascular disease incidence or on gastrointestinal . . . [Full Text of this Article]

Author Affiliations: Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Ga.

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