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Paclitaxel-Eluting Stents in Complex Lesions
Antonio Colombo, MD;
John Cosgrave, MD
JAMA. 2005;294:1268-1270.
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Percutaneous coronary interventions (PCIs) have become the dominant form of revascularization. This evolution has been based on the results of a large number of pivotal randomized trials. Since the pioneering work of Gruntzig,1 2 major developments have revolutionized clinical cardiology practice. The first was the introduction of bare metal stents by Sigwart and Puel in 1986 and results following use of stents to treat impending or acute vessel closure after balloon angioplasty were subsequently reported in 1987.2 Stent implantation improved both acute and long-term results following angioplasty, but perhaps more important from the patient’s perspective, dramatically reduced the need for emergency coronary artery bypass graft (CABG) surgery.
The second development was the advent of drug-eluting stents in an effort to prevent a need for repeat revascularization due to restenosis. Multiple studies comparing PCI with CABG surgery have shown that the superiority of CABG surgery . . . [Full Text of this Article]
Author Affiliations: Department of Cardiology, Columbus and San Raffaele Hospitals, Milan, Italy.
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