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Skin Cancer’s Ranks Rise
Immunosuppression to Blame
Tracy Hampton, PhD
JAMA. 2005;294:1476-1480.
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Chicago—Ever-growing numbers of individuals are at increased risk of developing skin cancer, and not just because of sun worship and the pursuit of the perfect tan. More people are susceptible now because of impaired immunity due to immunosuppressive drugs following organ transplantation or for various rheumatologic and dermatologic conditions. Also vulnerable are patients who have compromised immune surveillance due to such conditions as HIV and chronic lymphocytic leukemia (CLL), which increases their risk of developing cancer.
While such individuals present a challenge to physicians, their conditions can help shed light on the mechanisms involved and may therefore provide opportunities for therapeutic innovations.
TRANSPLANT RECIPIENTS
"Skin cancer is the most common malignancy in the posttransplant setting and affects the majority of patients eventually," said Clark Otley, MD, of the Mayo Clinic and Mayo Medical School, in Rochester, Minn, during the annual meeting of the American Academy of Dermatology held . . . [Full Text of this Article]
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Decreased Risk of Prostate Cancer after Skin Cancer Diagnosis: A Protective Role of Ultraviolet Radiation?
de Vries et al.
Am J Epidemiol 2007;165:966-972.
ABSTRACT
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Azathioprine, UV light, and skin cancer in organ transplant patients--do we have an answer?
Ulrich and Stockfleth
Nephrol Dial Transplant 2007;22:1027-1029.
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