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Electrocardiographic Effects of a Dietary Supplement Containing Ephedra and Caffeine—Reply
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In Reply: As noted by Dr Milic and colleagues, we used the incorrect formula taken from the article by Moss.1 We have recalculated our results using the correct formula for linear corrected QTc intervals. When the Framingham Linear Correction is properly used, the differences in the postdosing QTc interval values between the DSEC and placebo groups are of the same magnitude and direction as those derived from the Bazett formula (20.3-millisecond increase with DSEC; 400.5 milliseconds [SD, 10.7] vs 380.2 milliseconds [SD, 15.3]; P<.001).
In response to the request for machine-calculated information, we note evidence that computer readings of ECGs are not as accurate as a manual reading.2 However, the Table presents the baseline and 5-hour computer-read HR, RR intervals, and QT intervals. Using the computer-read QT and RR intervals, we calculated the Framingham corrected QTc interval (QTc = QT+ [0.154*{1-RR}]). We could not locate the 5-hour ECG reading for every . . . [Full Text of this Article]
C. Michael White, PharmD
cmwhite@harthosp.org
Department of Pharmacy Practice
University of Connecticut
Storrs
Brian F. McBride, PharmD
Division of Clinical Pharmacology
Vanderbilt University
Nashville, Tenn
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