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Tracy Hampton, PhD

JAMA. 2005;294:1608.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

DNA microarray tests that reveal patterns of gene activity show potential for better understanding human responses to injury and infection, according to new research findings published online in Nature on August 31 (Calvano et al. Available at: http://www.nature.com).

The study authors, a muti-institutional research team from the National Institute of General Medical Sciences’ Inflammation and Host Response to Injury program, are investigating how the systemic inflammation that can occur in patients with injury or infection alters the expression of genes within white blood cells. Such gene expression patterns could help reveal underlying regulatory mechanisms of the inflammatory response, suggest therapeutic interventions, and (because patients respond differently to therapies) may allow physicians to tailor therapies specifically for individual patients.

The investigators injected healthy participants with endotoxin, a bacterial component that can cause sepsis in susceptible burn and trauma patients. (When injected into healthy individuals, endotoxin produces a . . . [Full Text of this Article]