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Roots of Psoriasis
Joan Stephenson, PhD
JAMA. 2005;294:1890.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Psoriasis researchers have long debated whether the condition begins as an immune system disorder that induces skin lesions or as a skin disease that has immunological effects. Now, findings from a study by researchers from Germany, France, and Austria suggest that psoriasis begins with changes in the skin that subsequently trigger involvement of the immune system (Zenz et al. Nature. 2005;437:369-375).
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Research suggests that psoriasis is a skin disorder with immunological effects rather than an immunological disease that affects skin. (Photo credit: Image from Arch Dermatol. 1999;135:187-192)
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After discovering that skin cells in psoriatic lesions in humans have reduced expression of JunB, a gene known to regulate cell proliferation, differentiation, stress response, and cytokine expression in various organs, the researchers induced psoriasislike skin lesions and arthritis in mice lacking JunB and a related gene, c-jun. To probe the role of the immune system in . . . [Full Text of this Article]
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