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Parvovirus B19 and Onset of Juvenile Dermatomyositis
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To the Editor: Juvenile dermatomyositis (JDM) is a systemic autoimmune disease characterized by chronic muscle and cutaneous inflammation of unknown cause; however, some studies have suggested that infectious agents may trigger the onset of JDM and other childhood systemic autoimmune diseases.1 Several studies have described the detection of parvovirus B19 DNA in skin or muscle of patients with JDM, adult dermatomyositis, and other systemic rheumatic diseases.2 Given the similarity of the disease presentation of JDM and parvovirus B19 infection, we performed a case-control study to determine if parvovirus B19 infection is associated with the onset of JDM.
Methods
A plasma sample and clinical questionnaire were obtained from 62 patients with JDM (45 girls, mean [SD] age, 9.7 [4.6] years) meeting probable or definite Bohan and Peter criteria3 as part of the Childhood Myositis Heterogeneity Study, a North American registry of patients with juvenile idiopathic inflammatory myopathies. All patients in our study . . . [Full Text of this Article]
Gulnara Mamyrova, MD, PhD;
Lisa G. Rider, MD
Environmental Autoimmunity Group
National Institute of Environmental Health Sciences
Laura Haagenson;
Susan Wong, BS;
Kevin E. Brown, MD
brownk@nhlbi.nih.gov
Hematology Branch
National Heart, Lung, and Blood Institute
National Institutes of Health
Department of Health and Human Services
Bethesda, Md
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